Hi I'm Rik (Rikuta Hamaya), MD, PhD, MS.

Researcher, Division of Preventive Medicine, Brigham and Women's Hospital


Thank you for viewing my profile!



Research Interests + representative work

1: Biomarkers/ Metabolomics

Efforts to provide interpretations of certain biomarkers.


Hamaya R, Mora S, Lawler PR, et al. Association of Plasma Branched Chain Amino Acid with Biomarkers of Inflammation and Lipid Metabolism in Women [published online ahead of print, 2021 Jul 15]. Circ Genom Precis Med. 2021;10.1161/CIRCGEN.121.003330. doi:10.1161/CIRCGEN.121.003330

Hamaya R, Ivey KL, Lee DH, et al. Association of diet with circulating trimethylamine-N-oxide concentration [published correction appears in Am J Clin Nutr. 2020 Dec 10;112(6):1656]. Am J Clin Nutr. 2020;112(6):1448-1455. doi:10.1093/ajcn/nqaa225



2: Coronary circulation 

Providing insights onto coronary physiology to guide intravascular treatment for coronary artery disease.


Hamaya R, van de Hoef TP, Lee JM, et al. Differential Impact of Coronary Revascularization on Long-Term Clinical Outcome According to Coronary Flow Characteristics: Analysis of the International ILIAS Registry. Circ Cardiovasc Interv. 2022;15(6):e011948. doi:10.1161/CIRCINTERVENTIONS.121.011948

Hamaya R, Yonetsu T, Kanaji Y, et al. Diagnostic and Prognostic Efficacy of Coronary Flow Capacity Obtained Using Pressure-Temperature Sensor-Tipped Wire-Derived Physiological Indices. JACC Cardiovasc Interv. 2018;11(8):728-737. doi:10.1016/j.jcin.2018.01.249

Hamaya R, Mittleman MA, Hoshino M, et al. Prognostic Value of Prerevascularization Fractional Flow Reserve Mediated by the Postrevascularization Level. JAMA Netw Open. 2020;3(9):e2018162. Published 2020 Sep 1. doi:10.1001/jamanetworkopen.2020.18162


3: Physical Activity

Step count is an emerging biomarker to which I am working on making evidence.


Hamaya R, Mori M, Miyake K, Lee IM. Association of Smartphone-Recorded Steps Over Years and Change in Cardiovascular Risk Factors Among Working-Age Adults. J Am Heart Assoc. 2022;11(14):e025689. doi:10.1161/JAHA.121.025689

Hamaya R, Fukuda H, Takebayashi M, et al. Effects of an mHealth App (Kencom) With Integrated Functions for Healthy Lifestyles on Physical Activity Levels and Cardiovascular Risk Biomarkers: Observational Study of 12,602 Users. J Med Internet Res. 2021;23(4):e21622. Published 2021 Apr 26. doi:10.2196/21622


4: Causal inference methods

Especially interested in effect heterogeneity.

..... coming soon



Education & Training

PhD in Population Health Science – Cardiovascular Epidemiology. Harvard University, 2023

MS in Biostatistics – Cardiovascular Epidemiology. Harvard University, 2023

MS in Epidemiology. Harvard T.H. Chan School of Public Health, 2019

MD & BSc. Tokyo Medical and Dental University, 2013

Completed internal medicine residency: Tokyo Medical and Dental University Hospital

Completed cardiology fellowship: Tsuchiura Kyodo General Hospital



Awards & Grants

Certificate of Distinction, Harvard T.H. Chan School of Public Health, 2021

Research Fellowship, The Uehara Memorial Foundation, 2019

Research award, Tokyo Medical and Dental University, 2018 & 2019

Best Presentation Award, Functional Revascularization Encouraged by Optimal Diagnostic Strategy Live, 2018

Overseas Scholarship, The Nakajima Foundation, 2017

Best Poster Award, European Society of Cardiology Congress, 2017

Platinum Award, Beyond Angiography Japan XXI, 2016




Please see here in Pubmed




The other contents in this blog are written in Japanese - about causal inference methods, nutrition evidence, etc.

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