Hi I'm Rik (Rikuta Hamaya), MD, SM.

PhD candidate, Department of Epidemiology, Harvard Graduate School of Art and Science

Researcher, Division of Preventive Medicine, Brigham and Women's Hospital


Thank you for viewing my profile!



Research Interests + representative work

1: Metabolomics + Cardiovascular primary prevention

Everybody knows primary prevention is most important - I am obsessed to do 'practically meaningful' research to advance primary prevention.

I believe a) providing interpretations for biomarkers and b) exploring effect heterogeneity are of particular importance for this purpose.


Here are some a)s:

Hamaya R, Mora S, Lawler PR, et al. Association of Plasma Branched Chain Amino Acid with Biomarkers of Inflammation and Lipid Metabolism in Women [published online ahead of print, 2021 Jul 15]. Circ Genom Precis Med. 2021;10.1161/CIRCGEN.121.003330. doi:10.1161/CIRCGEN.121.003330

Hamaya R, Ivey KL, Lee DH, et al. Association of diet with circulating trimethylamine-N-oxide concentration [published correction appears in Am J Clin Nutr. 2020 Dec 10;112(6):1656]. Am J Clin Nutr. 2020;112(6):1448-1455. doi:10.1093/ajcn/nqaa225


b)s are coming soon!


2: Coronary intervention + physiology 

I believe the indication of coronary revascularization strategy (i.e. PCI and CABG) should be more optimized with evidence, especially in patients with stable angina.

Fractional flow reserve (FFR) is being used as a golden standard - I have been proposing coronary flow capacity as the additional index to optimally guide revascularization.

I have also been investigating the prognostic implication of FFR. This really needs epidemiology insights!


<Coronary flow capacity>

Hamaya R, Lee JM, Hoshino M, et al. Clinical outcomes of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention By Coronary Flow Capacity Status in Stable Lesions [published online ahead of print, 2020 Jul 7]. EuroIntervention. 2020;EIJ-D-20-00401. doi:10.4244/EIJ-D-20-00401

Usui E, Hamaya R, Kanaji Y, et al. Prevalence of OCT-Defined TCFA in Relation to CFC Classified With Pressure-Temperature Sensor-Tipped Wire. JACC Cardiovasc Imaging. 2019;12(9):1885-1887. doi:10.1016/j.jcmg.2019.02.017

Hamaya R, Yonetsu T, Kanaji Y, et al. Diagnostic and Prognostic Efficacy of Coronary Flow Capacity Obtained Using Pressure-Temperature Sensor-Tipped Wire-Derived Physiological Indices. JACC Cardiovasc Interv. 2018;11(8):728-737. doi:10.1016/j.jcin.2018.01.249


<Fractional flow reserve>

Hamaya R, Mittleman MA, Hoshino M, et al. Prognostic Value of Prerevascularization Fractional Flow Reserve Mediated by the Postrevascularization Level. JAMA Netw Open. 2020;3(9):e2018162. Published 2020 Sep 1. doi:10.1001/jamanetworkopen.2020.18162


3: Mobile Health

Mobile health (mHealth) apps can be powerful tools to advance public health.

I have been working as an epidemiological/medical consultant at several IT companies to build evidence of such apps.


Hamaya R, Fukuda H, Takebayashi M, et al. Effects of an mHealth App (Kencom) With Integrated Functions for Healthy Lifestyles on Physical Activity Levels and Cardiovascular Risk Biomarkers: Observational Study of 12,602 Users. J Med Internet Res. 2021;23(4):e21622. Published 2021 Apr 26. doi:10.2196/21622


4: Causal inference methods

Especially interested in effect heterogeneity.

..... coming soon



Education & Training

MS in Epidemiology. Harvard T.H. Chan School of Public Health, 2019

MD & BSc. Tokyo Medical and Dental University, 2013

Completed internal medicine residency: Tokyo Medical and Dental University Hospital

Completed cardiology fellowship: Tsuchiura Kyodo General Hospital



Awards & Grants

Certificate of Distinction, Harvard T.H. Chan School of Public Health, 2021

Research Fellowship, The Uehara Memorial Foundation, 2019

Research award, Tokyo Medical and Dental University, 2018 & 2019

Best Presentation Award, Functional Revascularization Encouraged by Optimal Diagnostic Strategy Live, 2018

Overseas Scholarship, The Nakajima Foundation, 2017

Best Poster Award, European Society of Cardiology Congress, 2017

Platinum Award, Beyond Angiography Japan XXI, 2016




Please see here in Pubmed




The other contents in this blog are written in Japanese - about causal inference methods, nutrition evidence, etc.

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